ESTUDIO WHI, REVISTA DE MENOPAUSIA, SALUD, REVISTAS MÉDICAS. Actualidad Inmediata Debido a la importancia de esta investigación y al impacto en. WHI. Progestin. Estrogen. Tibolone. Cardiovascular disease. Tromboembolic disease . Boletín de la Asociación Española para el Estudio de la Menopausia, . Los trastornos de la menopausia pueden ser evitados y combatidos Sin embargo, recientes estudios, como el estudio WHI, han puesto en duda los beneficios.

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Hu FB, Grodstein F. Where are we now? The Nurses’ Health Study and studies from Europe, where estradiol is the commonly prescribed form of menoppausia, suggest that the estrogen at lower doses esutdio confer similar benefit” [ 15 ] Luckily one has nowadays an ample choice of strategies and drugs hormonal and non-hormonal that enable a conscientious physician to do his best to restore the confidence of those women who have sought esstudio help. Primum, non nocereneither by excess nor by abstention, as well Furberg CD, et al.

To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior. Cancer Causes Control, 13pp.

Menkpausia Health Initiative Investigators. Obstet Gynecol,pp. Amer J Clin Nutr, 78pp. Which clinical studies provide the best evidence? Cancer Epidemiol Biom Prev, 11pp. Am J Cardiol, 85pp.

What is important is the best possible approach to preventive medicine in a mid-aged woman. J Clin Endocrinol Metab, 87pp.

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It must be emphasized that the WHI report stresses that the results do not necessarily apply to lower dosages of those drugs, to other formulations of oral estrogen and progestin or to estrogens and progestins administered through the transdermal route [ 1 ]. Are you a health professional able to prescribe or dispense drugs? Remember the CACS study, an open coronary calcification study that was started msnopausia the termination of the estrogen-alone arm trial, when it menopasuia evident that the younger WHI age group menopusia have benefited from therapy.


Dietary soy has both beneficial and potencially adverse cardiovascular effects: Thus this fixed excessive dose for older women does not necessarily reflect optimal good clinical practice and is not followed by any responsible gynaecologist. Cardiovascular disease outcomes during 6.

We present the study rationale and design. Estos datos fueron publicados en una serie de manuscritos durante el periodo — Br J Nutr, 89pp. Si continua navegando, consideramos que acepta su uso. Breast and uterine effects of soy isoflavones and conjugated estrogens in postmenopausal female monkeys. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy postmenopausal women.

It would suggest that if women were treated during one year there would be less than one woman with an adverse effect. This is a sign of excessive dose for women between It was meant to prove the clinical effectiveness of ONE specific estrogen and progestin to prevent heart disease.

It must be made clear that the concept of HRT does not mean that all postmenopausal women must be always under hormonal treatments [ 11 and 12 ]. Role of the gut flora in toxicity and cancer, pp.

Although there are no results yet from this ongoing study, it already carries an important message. Clin Endocrinol Oxf56pp.

Pooling data for estrogen alone and estrogen plus progestin resulted in increased risks for both endpoints. It demonstrates a post-factum change in perceptions about the potential effects of HT on cognitive brain function and brain aging.


The increased risk of breast cancer became apparent only after the fourth year of treatment. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Phytoestrogens and carcinogenesis—Differential effects of genistein in experimental models of normal and malignant rat endometrium. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but non premenopausal women.

Menopause, 6pp. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women.


Phytochemistry, 65pp. Clin Invest Gin Obst. To reassess the need of HRT after four years of therapy and not recommend HRT for the sole purpose of preventing chronic disease, such as cardiovascular disease or osteoporosis as other alternatives are available To promote the use of additional and alternative non-hormonal strategies for maintaining health and preventing disease in symptom free women of middle age and beyond. The WHI decision to stop the estrogen progestin arm does not necessarily change a wise clinician’s decision as to the best clinical care of a postmenopausal woman.

So the issue of possible effects of HT on cognitive esyudio and brain aging in young postmenopausal women is still open until further, good-quality data are available. Differences in effects between cognitive domains suggest that more than one mechanism may be involved. Breast cancer risk following long-term oestrogen and oestrogen-progestin replacement therapy.