Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.
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The penetration of GI fluids through the outer membrane causes the expansion of the swelling agent. In this technology, one or more drug compounds remain encapsulated to express release of drug in a pre-determined fashion.
This multiparticulate system provides sophisticated control of drug delivery and optimizes release profiles for single drugs and drug combinations.
Minitabs in multiparticulate drug delivery.
Controlled release delivery system by an osmotic bursting mechanism. A hydrostatic pressure generate inside the diffudaps that is why pulsatile drug delivery achieved4, 8, tcehnology, Covera-HS is the only controlled-release verapamil formulation that is currently approved with an indication for the management of both hypertension high blood pressure and angina pectoris chest pain.
Under the influence of electric field, electro-responsive hydro gels generally bend, depending on the shape of the gel which lies parallel to the electrodes whereas deswelling occurs when the hydro gel lies perpendicular to the electrodes 1, 2,3,15 Light induces release In this system drug delivery is regulated by the interaction between light and material and can be achieved by combining a material that absorbs light at a desired wavelength and a material that uses energy from the absorbed light to regulate drug delivery.
Indian journal of Pharmaceutical sciences Circadian changes are seen in normal lung function, which reaches a low point in the early morning hours. Compressed barrier layers for constant drug release in swellable matrix tablets.
Humans exhibit endogenous circadian rhythms that are regulated by the master circadian clock of the body, the suprachiasmatic nucleus. Polymers used for designing the hydrogel plug were various viscosity grades of hydroxyl propyl methyl cellulose, polymethyl methacrylates, polyvinyl acetate and poly ethylene oxide.
The rate of release is essentially independent of pH, posture and food. Classification of Pulsatile Drug Delivery Systems Pulsatile drug delivery systems can be classified in to three categories: Every Diffucaps bead has an inert core enclosed by drug as well as coated with a functional polymer membrane to control the rate of drug release.
International Journal of Drug Delivery ; 3: Circadian rhythms Circadian rechnology are self-sustaining, endogenous oscillations that occur with a periodicity of about 24 Hours Figure. The lag time increases with increasing coating thickness and hardness of the core table.
Gastro retentive drug delivery system is a suggestion to prolong gastric residence time, thereby targeting site-specific drug release in upper gastrointestinal GI tract. Multi-pulse drug delivery from a resorbable polymeric microchip device. Circadian rhythm regulates many body functions in humans, viz.
Recent technologies in pulsatile drug delivery systems
Some of them are enlisted as below:. Due to their high efficiency and lack of undesirable adverse effects to the whole body, the stimuli-responsive feature of these systems is useful for treatment of patients.
Multiparticulate Drug Delivery System. The release-controlling polymer is a technilogy of water soluble and water insoluble polymers. The objective of the study was to explore the time- and pH-dependent controlled drug delivery of Diclofenac Sodium using the pulsincap system. Chronotropic diffucapw consists of a core containing drug reservoir coated by a hydrophilic polymer HPMC. This review covers methods and marketed technologies that have been developed to achieve pulsatile delivery.
They reduce the dose diffucapz, dose size and cost, which ultimately reduces side effects, thereby improving patient compliance. These systems are designed according to the circadian rhythm of the body and the drug is released as a pulse. Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tablets. The drug layer contains the poorly soluble drugs, osmotic agents and a suspending agent.
Pulsatile Drug Delivery System: Trop J Pharm Res. The water insoluble polymer continues to act as a barrier maintaining the controlled release of drug. These systems are considered excellent delivery candidates, since they can be modified according to the task to be achieved. It is reported that the weak and non-flexible ethyl cellulose film ruptured adequately as compared with more flexible films. Technologg this technology, a bilayer tablet was manufactured. Eurand applied this technology to both soluble divfucaps insoluble products.
Externally Regulated System Magnetic induces release Magnetically regulated system contains magnetic beads in the implant.
Recent technologies in pulsatile drug delivery systems
Timing drug availability with therapeutic need. Scherer International Corporation Michigan. The push layer contains diffuucaps other things, an osmotic agent and water swellable polymers. In this, the beads with high density drug are compressed to form controlled release tablets. Diseases wherein PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia.
Int J Pharm Res Devel. Floating or pulsatile drug delivery systems based on coated effervescent cores. When the capsule comes in contact with dissolution fluid, the plug gets swells, and after a lag time, the plug pushes itself outside the capsule and rapidly releases the drug. This is possible by filling an additional magnetic component into capsules or tablets. Externally regulated pulsatile release system Electroresponsive pulsatile release An electric field as an external stimulus has advantages, such as availability of equipment that allows precise control with regard to the magnitude of the current, duration of electric pulses, interval between pulses, etc.
In aqueous solution, block copolymers formed micellar structure with core shell structure below PIPAAm’s transition temperature. Recent trends include Multiparticulate drug delivery systems that are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Due to its flexible and highly reproducible manufacturing process, 3DP has some advantages over conventional compressing and other RP technologies in fabricating solid DDS.
Lodotra TM has been designed so that maximum plasma levels are reached six hours after intake. By selecting the appropriate pH dependent polymers, desired drug release can be achieved at specific location.
A semipermeable membrane surrounds the tablet core.